Excluded Volume in Solvation: Sensitivity of Scaled-Particle Theory to Solvent Size and Density
نویسندگان
چکیده
منابع مشابه
Excluded volume in solvation: sensitivity of scaled-particle theory to solvent size and density.
Changes in solvent environment greatly affect macromolecular structure and stability. To investigate the role of excluded volume in solvation, scaled-particle theory is often used to calculate delta G(tr)(ev), the excluded-volume portion of the solute transfer free energy, delta G(tr). The inputs to SPT are the solvent radii and molarities. Real molecules are not spheres. Hence, molecular radii...
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Synopsis A comprehensive, semi-quantitative model for the thermodynamics of hydrophobic sol-vation is presented. The model is based on a very simple premise suggested by the scaled particle theory and treats both solute and solvent molecules as hard spheres. A connection between the peculiarly large heat-capacity change for hydrophobic solvation and the large temperature dependence of the therm...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2000
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(00)76470-8